A case of systemic lupus erythematosus complicated by progressive multifocal leukoencephalopathy: case report and review of the literature

Tohru AkahoshiDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Mamoru IshikawaDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Michio TakahashiDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Naho SekiyamaDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Kazuko HasegawaDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Kiyoharu WatanabeDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Yoshihiro IshiharaDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

Hirobumi KondoDepartments of Internal Medicine and Pathology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228, Japan

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Abstract

Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system caused by an opportunistic infection of the JC virus. PML is known to occur in immunocompromised patients. A patient with systemic lupus erythematosus (SLE) who developed PML during i.v. cyclophosphamide and methylprednisolone pulse therapy is described. The pertinent literature relating to complication of SLE by PML is discussed.

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A case of systemic lupus erythematosus complicated by progressive multifocal leukoencephalopathy: case report and review of the literature

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A case of systemic lupus erythematosus complicated by progressive multifocal leukoencephalopathy: case report and review of the literature

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