Studies on the Sensitivity of Proteus Mirabilis and Proteus Vulgaris to Sulphonamide and Colistin Alone and in Combination

Abstract

75 strains of Proteus mirabilis and 25 strains of Proteus vulgaris were isolated from urine, pus and throat swab specimens and tested for sensitivity to sulphonamide and colistin and these drugs in combination. It was found that all the strains were resistant to colistin and 52 of them also to a sulphonamide. A marked synergistic action of the two drugs was evident on 78 of the 100 strains and was present at concentrations of the drugs attainable in body fluids by therapy. The possible therapeutical implications of this finding are briefly discussed.