Cold Agglutinin Production and Cytomegalovirus Infection

Klaus Lind Blood Bank and Blood Grouping Department, Statens Seruminstitut, Copenhagen; the Medical, Department C, Aarhus Municipal Hospital; and the Department of Virology, Institute of Microbiology, Aarhus, Denmark

Edwin S. Spencer Blood Bank and Blood Grouping Department, Statens Seruminstitut, Copenhagen; the Medical, Department C, Aarhus Municipal Hospital; and the Department of Virology, Institute of Microbiology, Aarhus, Denmark

Hans Kerzel Andersen Blood Bank and Blood Grouping Department, Statens Seruminstitut, Copenhagen; the Medical, Department C, Aarhus Municipal Hospital; and the Department of Virology, Institute of Microbiology, Aarhus, Denmark

Abstract

By serological investigation of various groups of patients, a correlation was found between rise in titre of antibodies to cytomegalovirus (CMV) and rise in cold agglutinin (CA) titre. This correlation was most marked, and significant, in a group of renal graft recipients where 16 of 27 had roughly parallel rises in CA and CMV antibody titre. It is suggested that in most patients showing this correlation the production of CA was related to infection with CMV, and it is possible that this immunological feature is more common in patients with CMV pneumonia.

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Cold Agglutinin Production and Cytomegalovirus Infection

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Cold Agglutinin Production and Cytomegalovirus Infection

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