Pathogenicity in Mice of Strains of Candida Albicans with Different in Vitro Sensitivity to 5-Fluorocytosine

Monica Persson Departments of Pathology, University of Umeå, Umeå, Medical Microbiology, Linköping University, Linköping, and Surgery, Norrköping Hospital, Norrköping, Sweden

Bengt Winblad Departments of Pathology, University of Umeå, Umeå, Medical Microbiology, Linköping University, Linköping, and Surgery, Norrköping Hospital, Norrköping, Sweden

Steffan Ånséhn Departments of Pathology, University of Umeå, Umeå, Medical Microbiology, Linköping University, Linköping, and Surgery, Norrköping Hospital, Norrköping, Sweden

Jan Schönebeck Departments of Pathology, University of Umeå, Umeå, Medical Microbiology, Linköping University, Linköping, and Surgery, Norrköping Hospital, Norrköping, Sweden

Abstract

The pathogenicity in mice of 7 strains of Candida albicans with different in vitro susceptibility to 5-fluorocytosine (5-FC) was investigated. Resistant strains were not less virulent than susceptible strains. This is contradictory to findings reported for candida strains resistant to polyene antibiotics, which were less pathogenic than susceptible strains. The implications of these findings are discussed.

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Pathogenicity in Mice of Strains of Candida Albicans with Different in Vitro Sensitivity to 5-Fluorocytosine

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Pathogenicity in Mice of Strains of Candida Albicans with Different in Vitro Sensitivity to 5-Fluorocytosine

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