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Abstract
Between January 1976 and March 1977, cerebrospinal fluid samples from 2130 patients at University College Hospital, Ibadan, Nigeria were examined. 130 patients were shown to have pyogenic meningitis. The commonest causative bacteria were Streptococcus pneumoniae (53.8 %), Haemophilus influenzae (23 %), Neisseria meningitidis (7.7 %) and Klebsiella spp. (3 %). Most of the infections occurred in very young children: 47 % of all patients were under 1 year of age, and 69 % were under 5 years old. The overall case fatality rate was 30 % (Strep. pneumoniae infection 28.6 %, H. influenzae and N. meningitidis infection both 20 %). All 4 patients with klebsiella infection died. There was a noticeable increase in the incidence of Strep. pneumoniae strains showing resistance to tetracycline, between 1974 and 1976, and this was attributed to the widespread use and abuse of the antibiotic among the general population. Two strains of H. influenzae were found to be resistant to ampicillin; such strains have not previously been reported from Nigeria. The results of the study support the use of a combination of ampicillin and gentamicin in the initial treatment of pyogenic meningitis in Ibadan.