Tobramycin in Patients with Various Infections: A Clinical Evaluation

Abstract

22 patients with various gram-negative infections were treated with tobramycin at a dose of approximately 3 mg/kg body weight/24 h for 7 to 53 (mean 16) days. Therapy was monitored with determinations of drug serum concentrations and renal and audio-vestibular function tests. In 16 patients either cure or clinical improvement were achieved. Two patients did not improve. In another 4 patients the effect of tobramycin therapy could not be evaluated. One patient exhibited a subclinical vestibular dysfunction and one patient experienced transient tinnitus. In one patient, slight but clinically significant renal impairment occurred.