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Abstract
Tobramycin was used in the treatment of severe infections in infants, mostly newborns and prematures. Serum half-life of the drug was 3.5 h in infants older than one week and above 2 500 g, and 8.0 h in infants below one week and less than 2 500 g. Apparent volume of distribution was similar in both groups, 0.24 l/kg. Intravenous infusions of the drug gave considerably higher plasma levels than intramuscular injections. Particularly in the newborn and premature group intramuscular injections gave fairly unpredictable plasma concentrations.