Clindamycin Excretion in the Pancreatic Fluid of Dogs

Abstract

Clindamycin phosphate in dosage of 15 mg/kg was administered intravenously to dogs. Serum and pancreatic juice clindamycin concentrations were assayed. Pancreatic juice clindamycin concentrations varied between 1.32–5.5 μg/ml. Clindamycin was still detectable in the pancreatic juice 4½ h after its administration. Clindamycin, in combination with other antimicrobials, may be potentially effective in the prophylaxis and therapy of some of the infectious complications associated with pancreatitis.