Treatment of Experimental Naegleria Meningoencephalitis with a Combination of Amphotericin B and Rifamycin

Yee Hing Thong Department of Paediatrics, University of Adelaide, the Adelaide Children's Hospital, North Adelaide, South Australia, Australia

Brenton Rowan-Kelly Department of Paediatrics, University of Adelaide, the Adelaide Children's Hospital, North Adelaide, South Australia, Australia

Antonio Ferrante Department of Paediatrics, University of Adelaide, the Adelaide Children's Hospital, North Adelaide, South Australia, Australia

Abstract

The treatment of primary amoebic meningoencephalitis was examined using a mouse model. Rifamycin by itself was ineffective. However, a synergistic effect was observed when used in combination with amphotericin B. This finding may prove useful in the treatment of patients with primary amoebic meningoencephalitis, for which satisfactory treatment is currently unavailable.

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Treatment of Experimental Naegleria Meningoencephalitis with a Combination of Amphotericin B and Rifamycin

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Treatment of Experimental Naegleria Meningoencephalitis with a Combination of Amphotericin B and Rifamycin

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