Passive–Active Immunization in a Neonate Treated with Repeated Doses of High-Titred Hepatitis B Immune Globulin

Sten Iwarson Department of Infectious Diseases, University of Göteborg, East Hospital, Göteborg, the Institute of Medical Microbiology, Department of Clinical Virology, University of Göteborg, Göteborg, and the Institute of Medical Microbiology, Department of Virology, University of Lund, Lund, Sweden

Gunnar Norkrans Department of Infectious Diseases, University of Göteborg, East Hospital, Göteborg, the Institute of Medical Microbiology, Department of Clinical Virology, University of Göteborg, Göteborg, and the Institute of Medical Microbiology, Department of Virology, University of Lund, Lund, Sweden

Svante Hermodsson Department of Infectious Diseases, University of Göteborg, East Hospital, Göteborg, the Institute of Medical Microbiology, Department of Clinical Virology, University of Göteborg, Göteborg, and the Institute of Medical Microbiology, Department of Virology, University of Lund, Lund, Sweden

Erik Nordenfelt Department of Infectious Diseases, University of Göteborg, East Hospital, Göteborg, the Institute of Medical Microbiology, Department of Clinical Virology, University of Göteborg, Göteborg, and the Institute of Medical Microbiology, Department of Virology, University of Lund, Lund, Sweden

Abstract

A newborn infant, born to a HBsAg-positive drug addict with HBeAg and DNA-polymerase activity in serum, was treated with repeated very high doses of hepatitis B immune globulin (HBIg). The mother turned HBsAg-negative about 8 months after delivery and the HBIg prophylaxis was then discontinued. A check-up of the infant about a year later revealed normal liver function tests but significantly increased levels of antibodies against HBcAg and HBsAg indicating a past subclinical hepatitis B infection, apparently without harm to the infant.

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Passive–Active Immunization in a Neonate Treated with Repeated Doses of High-Titred Hepatitis B Immune Globulin

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Passive–Active Immunization in a Neonate Treated with Repeated Doses of High-Titred Hepatitis B Immune Globulin

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