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Case Report

Passive–Active Immunization in a Neonate Treated with Repeated Doses of High-Titred Hepatitis B Immune Globulin

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Pages 167-169 | Published online: 02 Jan 2015
 

Abstract

A newborn infant, born to a HBsAg-positive drug addict with HBeAg and DNA-polymerase activity in serum, was treated with repeated very high doses of hepatitis B immune globulin (HBIg). The mother turned HBsAg-negative about 8 months after delivery and the HBIg prophylaxis was then discontinued. A check-up of the infant about a year later revealed normal liver function tests but significantly increased levels of antibodies against HBcAg and HBsAg indicating a past subclinical hepatitis B infection, apparently without harm to the infant.

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