Mycoplasma Pneumoniae Pneumonia Associated with Iga Nephropathy

Yoshiharu Kanayama First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

Kenzo Shiota First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

Kazunori Kotumi First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

Yoshiyasu Ikuno First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

Ryoji Yasumoto Department of Urology, Osaka City University Medical School, Osaka, Japan

Masamitsu Ishii Department of Dermatology, Osaka City University Medical School, Osaka, Japan

Takatoshi Inoue First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan

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Abstract

An 18-yr-old male developed Mycoplasma pneumoniae pneumonia associated with IgA nephropathy. In the biopsied renal tissue, immunofluorescence showed striking deposits of IgA, C3 and C3 activator in the mesangium, and electron microscopic examination showed electron-dense deposits in the mesangial region. When the patient's serum was preincubated with rabbit antiserum to human IgA, the passive hemagglutination titer for M. pneumoniae was much decreased. We suggest that in some cases, IgA nephropathy may follow infection by an organism which stimulates an IgA antibody response, leading to the formation of IgA antigen-antibody immune complex deposits in the glomerular mesangium.

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Mycoplasma Pneumoniae Pneumonia Associated with Iga Nephropathy

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Mycoplasma Pneumoniae Pneumonia Associated with Iga Nephropathy

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