Adduct Formation Is Involved in Radiosensitization, Mediated by Cytochrome c, of ϕϕX174 DNA by Misonidazole

M.V.M. Lafleur Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

E.J. Plijmackers-Westmijze Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

A.C. Loman Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

H. Loman Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

Abstract

Radiosensitization by misonidazole of biologically active &#123 X174 DNA, mediated by cytochrome c, is most probably at least partly due to formation of an adduct between sensitizer and DNA, which can be removed from the DNA by a mild alkaline treatment thereby restoring the activity of the DNA.

Keywords

Adduct Formation, Misonidazole, Dna, Cytochrome c

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Adduct Formation Is Involved in Radiosensitization, Mediated by Cytochrome c, of ϕϕX174 DNA by Misonidazole

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Adduct Formation Is Involved in Radiosensitization, Mediated by Cytochrome c, of ϕϕX174 DNA by Misonidazole

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