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CASE REPORT

Expansion of large granular lymphocytes following Pseudomonas infection in a patient with adult-onset Still's disease

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Pages 101-104 | Received 21 Nov 2005, Accepted 14 Feb 2006, Published online: 02 Jan 2014
 

Abstract

We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without any evidence of active viral activation, hemophagocytosis, or malignancies. The increased LGL cells were CD3(+)CD8(+), and disappeared promptly after the administration of antibiotics combined with prednisolone, with subsequent stabilization of her general condition.

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