A pediatric patient with neuro-Behçet’s disease

Saori HatachiDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Takashi NakazawaDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Akio MorinobuDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Shinpei KasagiDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Yoshinori KogataDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Gohichi KageyamaDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Seiji KawanoDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Masahiro KoshibaDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, Japan

Shunichi KumagaiDepartment of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku 650-0017 Kobe, JapanCorrespondence[email protected]

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Abstract

Behçet’s disease is rare in childhood. We describe a 10-year-old boy with neuro-Behçet’s disease (NB) who presented with fever, headache, vertigo, and hearing loss. An examination of the cerebrospinal fluid (CSF) revealed pleocytosis as well as elevated protein and interleukin (IL)-6 levels. Brain magnetic resonance imaging (MRI) showed hyperintensity of the right thalamus and midbrain on T2-WI, and gadolinium (Gd) enhancement of left acoustic nerve origin. HLA-B51 was positive. Prednisolone combined with methotrexate resulted in a complete remission. Brain MRI and the CSF IL-6 level were useful for the diagnosis and monitoring of this pediatric patient with NB.

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A pediatric patient with neuro-Behçet’s disease

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A pediatric patient with neuro-Behçet’s disease

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