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CASE REPORT

Klinefelter’s syndrome associated with systemic lupus erythematosus and autoimmune hepatitis

, , , , &
Pages 305-308 | Received 16 Mar 2006, Accepted 12 Jun 2006, Published online: 02 Jan 2014
 

Abstract

Klinefelter’s syndrome (KFS) tends to be associated with immunological disorders. We describe a 37-year-old man who presented signs of testicular atrophy and decreased body hair. He showed pancytopenia and elevated levels of liver enzymes. Chromosome analysis revealed 47XXY karyotype; therefore, he was diagnosed with KFS, with systemic lupus erythematosus and autoimmune hepatitis. Treatment with a high dose of methylprednisolone and methyltestosterone improved thrombocytopenia and symptoms, suggesting that methyltestosterone may have a clinical benefit in the treatment of KFS with a low level of testosterone accompanying immunological disorders.

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