A case of Castleman's disease associated with diffuse idiopathic skeletal hyperostosis and ossification of the posterior longitudinal ligament of the spine

Shu KobayashiDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Shigeki MomoharaDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, JapanCorrespondence[email protected]

Katsunori IkariDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Takeshi MochizukiDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Koichiro KawamuraDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

So TsukaharaDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Kazumasa NishimotoDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Hiroshi OkamotoDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

Taisuke TomatsuDepartment of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University,10-22 Kawada, Shinjuku-ku, Tokyo 162-0054, Japan

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Abstract

Castleman's disease (CD), diffuse idiopathic skeletal hyperostosis (DISH), and ossification of the posterior longitudinal ligament of the spine (OPLL) are three different entities. Castleman's disease displaying a variety of calcifications in the abdomen and/or pelvis has been reported in some papers. However, there were no reports suggesting an association between CD and ossification/calcification in spine and joints. So far, there has been no case report regarding the coexistence of these diseases in the literature. Herein, we detail a 75-year-old man suffering from CD who demonstrated the features of DISH with coexisting features of OPLL. The cardinal symptoms such as fatigue, high fever, and swollen glands in this case were reduced by corticosteroid therapy. However, it is possible to produce actual symptoms of ossifying/calcified diathesis of entheses and ligaments as a consequence, like the pathology of calcification found in the region of the spleen. In this paper, we describe this patient in order to discuss the association of these diseases.

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A case of Castleman's disease associated with diffuse idiopathic skeletal hyperostosis and ossification of the posterior longitudinal ligament of the spine

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A case of Castleman's disease associated with diffuse idiopathic skeletal hyperostosis and ossification of the posterior longitudinal ligament of the spine

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