Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state

Tomoki ItoFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Yoshio OzakiFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, JapanCorrespondence[email protected]

Keiko ShimamotoFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Hideki AmuroFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Tsutomu TanijiriFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Takashi YokoiFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Yonsu SonFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Kenichirou TajimaFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

Shirou FukuharaFirst Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan

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Abstract

Adult-onset Still’s disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.

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Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state

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Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state

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