A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica

Hideki NakamuraUnit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, JapanCorrespondence[email protected]

Kayo Kamiya-MatsumotoUnit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan

Atsushi KawakamiUnit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan

Hiroaki IdaUnit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan

Tomayoshi HayashiDepartment of Pathology, Nagasaki University Hospital, Nagasaki, Japan

Shinichi SatoDepartment of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Shimeru KamihiraCentral Diagnostic Laboratory, Nagasaki University Hospital, Nagasaki, Japan

Katsumi EguchiUnit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan

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Abstract

A 60-year-old male who had been treated for polymyalgia rheumatica (PMR) with Raynaud’s phenomenon was admitted to our hospital with acrocyanosis and rapid progressive anemia. Hemolytic anemia with reduction of haptoglobin and cold agglutinin was detected, and the patient had a negative Donath-Landsteiner test. A skin biopsy from his toe revealed microthromboembolism without vasculitis, resulting in the diagnosis of cold agglutinin disease (CAD). This is a first case report of CAD complicated with PMR.

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A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica

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A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica

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