Kikuchi–Fujimoto disease developed into autoimmune disease: a report of two cases

Abstract

We report herein the pathological findings and clinical courses of two cases of Kikuchi–Fujimoto disease (KFD) that developed into autoimmune diseases. The patients are currently undergoing treatment for a disease similar to Sjogren’s syndrome and systemic lupus erythematosus/mixed connective tissue disease. KFD is not an independent condition and most likely develops due to an autoimmune mechanism. Pediatricians should pay careful attention to KFD and encourage long-term follow-up in patients with this condition.

Keywords::

• Kikuchi–Fujimoto disease
• Histiocytic necrotizing lymphadenitis
• Autoimmune disease
• Systemic lupus erythematosus
• Sjogren’s syndrome