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Modern Rheumatology Volume 22, 2012 - Issue 4
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Case Report

Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases

Takehiro TakahashiDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
,
Yoshihide AsanoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanCorrespondence[email protected]
,
Eisuke AmiyaDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Masaru HatanoDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Zenshiro TamakiDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
,
Atsuko OzekiDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Aya WatanabeDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Shuichi KawarasakiDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Tomoko NakaoDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Takashi TaniguchiDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
,
Yohei IchimuraDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
,
Tetsuo ToyamaDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
,
Masafumi WatanabeDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Yasunobu HirataDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
,
Ryozo NagaiDepartment of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
&
Shinichi SatoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
 show all
Pages 598-601 | Received 05 Apr 2011, Accepted 26 Sep 2011, Published online: 02 Jan 2014
 
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Abstract

Intravenous cyclophosphamide pulse therapy (IVCY) exerts its efficacy against interstitial lung disease (ILD) associated with systemic sclerosis (SSc) by restoring vascular injuries as well as aberrant immune activation. We recently experienced two patients with SSc-ILD in whom the values of brachial flow-mediated dilation (FMD) reflected the efficacy of IVCY. We herein report the details of these cases and discuss the potential of FMD to predict and evaluate the effect of IVCY on SSc-ILD.

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