Identification of the proto-oncogene c-fos in areas of periprosthetic osteolysis around loosened hip prostheses

C. ChibaDepartment of Orthopaedic Surgery, Daini Hospital, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan

J. ChibaDepartment of Orthopaedic Surgery, Daini Hospital, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan

M. OyamaDepartment of Orthopaedic Surgery, Daini Hospital, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan

K. InoueDepartment of Orthopaedic Surgery, Daini Hospital, Tokyo Women's Medical University, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan

Abstract

Expression of the proto-oncogene c-fos was investigated by in situ hybridization and a study of the immunohistochemistry of the interfacial membranes surrounding the femoral component of failed cementless total hip arthroplasty (THA). The values of the proto-oncogene c-fos gene and protein were high in these interfacial membranes. High expression of the c-fos gene and protein was observed in the macrophage-like cells and fibroblast-like cells. However, there was little expression in multinucleated giant cells. We demonstrated the significance of the proto-oncogene c-fos in interfacial membranes – the first report of c-fos in total joint replacement failure.

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Identification of the proto-oncogene c-fos in areas of periprosthetic osteolysis around loosened hip prostheses

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Identification of the proto-oncogene c-fos in areas of periprosthetic osteolysis around loosened hip prostheses

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