An autopsy case of hepatitis B (HB) antigen-positive polyarteritis nodosa, with reference to immunopathological studies of vascular lesions

T. NonogakiDivision of Locomotorial Disorders, Institute for Medical Science of Aging, Aichi Medical University, 5-1206 Akaike, Nissin, Aichi 470-0125, Japan

S. AokiDivision of Locomotorial Disorders, Institute for Medical Science of Aging, Aichi Medical University, 5-1206 Akaike, Nissin, Aichi 470-0125, JapanCorrespondence[email protected]

K. YoshikawaDivision of Locomotorial Disorders, Institute for Medical Science of Aging, Aichi Medical University, 5-1206 Akaike, Nissin, Aichi 470-0125, Japan

T. MitsuiDivision of Locomotorial Disorders, Institute for Medical Science of Aging, Aichi Medical University, 5-1206 Akaike, Nissin, Aichi 470-0125, Japan

Abstract

An autopsy case of an 11-year-old boy with polyarteritis nodosa is described in which the onset of the disease was associated with the presence of hepatitis B (HB) antigens (Ag) in the cytoplasm and nuclei of hepatocytes as detected by immunohistological methods. Deposits of HBsAg, HBeAg, IgG, IgM, C3, and C1q were demonstrated in systemic vascular lesions. It is considered that the arteritis was due to deposition in the arteries of immune complexes formed by HBAg and HB antibodies.

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An autopsy case of hepatitis B (HB) antigen-positive polyarteritis nodosa, with reference to immunopathological studies of vascular lesions

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An autopsy case of hepatitis B (HB) antigen-positive polyarteritis nodosa, with reference to immunopathological studies of vascular lesions

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