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Modern Rheumatology Volume 11, 2001 - Issue 2
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CASE REPORT

Systemic sclerosis in two second cousins: a case report

T. KurodaDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, JapanCorrespondence[email protected]
,
S. MurakamiDepartment of Rheumatology, Niigata Prefectural Senami Hospital, Murakami, Niigata, Japan
,
S. HondaDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
,
Y. OhfuchiDepartment of Rheumatology, Niigata Prefectural Senami Hospital, Murakami, Niigata, Japan
,
S. HiroseDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
,
H. HasegawaDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
,
A. MurasawaDepartment of Rheumatology, Niigata Prefectural Senami Hospital, Murakami, Niigata, Japan
,
M. NakanoDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
&
F. GejyoDepartment of Medicine II, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
 show all
Pages 168-171 | Received 20 Sep 2000, Accepted 09 Jan 2001, Published online: 02 Jan 2014
 
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Abstract

We describe two second cousins who developed systemic sclerosis. These patients had major histocompatibility complex (MHC) class I alleles in common, including A2, A26(10), B60(40), and Cw7 as well as class II allele DR2. This DR2 was thought to be associated with the onset of the disease. Our patients both experienced a limited type of systemic sclerosis, but the expression of autoantibodies was different.

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