532
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Canadian cost-effectiveness analysis of solifenacin compared to oxybutynin immediate-release in patients with overactive bladder

, &
Pages 508-515 | Accepted 15 Jul 2010, Published online: 09 Aug 2010
 

Abstract

Objective:

To estimate the cost effectiveness of solifenacin 5 mg/day compared to oxybutynin immediate-release (IR) 15 mg/day in patients with overactive bladder, from the perspective of the Canadian healthcare (payer) system.

Research design and methods:

A Markov model was adapted to estimate the incremental cost per quality-adjusted life-year (QALY) of solifenacin and oxybutynin IR over a 1-year time horizon, based on efficacy and discontinuation data from the Canadian VECTOR (VEsicare in Comparison To Oxybutynin for oveRactive bladder patients) study. In the model, patients who discontinued treatment were offered tolterodine extended release 4 mg/day as second-line. Model robustness was tested using various sensitivity analyses. Utility values were derived from published literature; incontinence pads were included in a secondary analysis.

Results:

In the base-case analysis, total costs over 1 year were CAN$695 and CAN$550 in the solifenacin and oxybutynin IR groups, respectively. When including incontinence pad costs, there was an incremental saving of CAN$1,831 per patient with solifenacin. Solifenacin was associated with an incremental QALY gain of 0.01 over 1 year. In the base-case analysis without incontinence pads, the incremental cost-utility ratio for solifenacin was CAN$14,092. Probabilistic analyses showed no overlap in the 95% confidence intervals for total costs or QALYs with or without incontinence pads. Solifenacin was cost effective in >90% of cases, based on a willingness-to-pay threshold of CAN$50,000 per additional QALY, irrespective of whether pad costs were included in the model. The most influential variables were the discontinuation rates and the cost of incontinence pads. Limitations of the analysis relate mainly to the fact that data in the VECTOR study were collected using a direct questioning approach, which might have increased the reporting of dry mouth.

Conclusions:

Solifenacin 5 mg/day was a cost-effective treatment compared with oxybutynin IR 15 mg/day.

Conclusions:

NCT00431041 (of the VECTOR study, upon which the analysis in this paper was based).

Transparency

Declaration of funding

This was supported by a research grant from Astellas Pharma Canada, Inc.

Declaration of financial/other relationships

The authors declare the following for relevant research, consultancy and/or advisory work: S.H. has disclosed that he has been involved in research, consultancy and/or advisory work for Astellas, Pfizer, Allergan, Coloplast, Johnson & Johnson, and American Medical Systems.

C.V. and C.P. have disclosed that they are employees of PIVINA Consulting Inc., a company that received funding from Astellas to conduct this study.

Acknowledgments

Medical writing and editorial assistance were provided by S. Sharpe PhD of SharpeCom Ltd, funded by Astellas Pharma Canada, Inc.

Some of the results of this study were presented as an abstract and poster at the 34th Annual meeting of the International Urogynaecological Association (IUGA), Como, Italy, June 16–20, 2009 (poster 569).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.