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Archives of Environmental & Occupational Health Volume 60, 2005 - Issue 1
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Original Article

Genetic Influences on the Retention of Inorganic Mercury

Hipolito M. Custodio MD Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
,
Raul Harari PhD Corporacion Para el Desarrollo de la Producción y el Medio Ambiente Laboral (Association for the Development of Production and the Workplace), Quito, Ecuador
,
Lars Gerhardsson MD Department of Sahlgrenska University Hospital, Occupational and Environmental Medicine, Göteborg, Sweden
,
Staffan Skerfving MD Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
&
Karin Broberg DMedSci Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
Pages 17-23 | Published online: 07 Aug 2010
 
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Abstract

Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.

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