Advanced search
Publication Cover
Archives of Environmental & Occupational Health Volume 60, 2005 - Issue 1
Submit an article Journal homepage
175
Views
58
CrossRef citations to date
0
Altmetric
Original Article

Genetic Influences on the Retention of Inorganic Mercury

Hipolito M. Custodio MD Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
,
Raul Harari PhD Corporacion Para el Desarrollo de la Producción y el Medio Ambiente Laboral (Association for the Development of Production and the Workplace), Quito, Ecuador
,
Lars Gerhardsson MD Department of Sahlgrenska University Hospital, Occupational and Environmental Medicine, Göteborg, Sweden
,
Staffan Skerfving MD Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
&
Karin Broberg DMedSci Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
Pages 17-23 | Published online: 07 Aug 2010
 
Sample our Economics, Finance,Business & Industry journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Immunotoxic Effects of Mercury
Source: Springer Vienna
An Investigation of Modifying Effects of Metallothionein Single-Nucleotide Polymorphisms on the Association between Mercury Exposure and Biomarker Levels
Source: Environmental Health Perspectives
Biomarkers of mercury toxicity: Past, present, and future trends.
Source: Informa UK Limited
A review of mercury exposure among artisanal small-scale gold miners in developing countries.
Source: Springer Science and Business Media LLC
Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor.
Source: Informa UK Limited
Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview.
Source: MDPI AG
Adverse Effects of Low Level Heavy Metal Exposure on Male Reproductive Function
Source: Informa UK Limited
Ecogenetics of mercury
Source: Wiley
Mercury in human brain, blood, muscle and toenails in relation to exposure: an autopsy study.
Source: Springer Nature

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.