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Abstract
Posttraumatic stress disorder (PTSD) and other deployment-related outcomes originate from a complex interplay between constellations of changes in DNA, environmental traumatic exposures, and other biological risk factors. These factors affect not only individual genes or bio-molecules but also the entire biological networks that in turn increase or decrease the risk of illness or affect illness severity. This review focuses on recent developments in the field of systems biology which use multidimensional data to discover biological networks affected by combat exposure and post-deployment disease states. By integrating large-scale, high-dimensional molecular, physiological, clinical, and behavioral data, the molecular networks that directly respond to perturbations that can lead to PTSD can be identified and causally associated with PTSD, providing a path to identify key drivers. Reprogrammed neural progenitor cells from fibroblasts from PTSD patients could be established as an in vitro assay for high throughput screening of approved drugs to determine which drugs reverse the abnormal expression of the pathogenic biomarkers or neuronal properties.
For the abstract or full text in other languages, please see Supplementary files under Article Tools online
This paper is part of the Special Issue: PTSD in the military: prevalence, pathophysiology, treatment. More papers from this issue can be found at http://www.eurojnlofpsychotraumatol.net
For the abstract or full text in other languages, please see Supplementary files under Article Tools online
This paper is part of the Special Issue: PTSD in the military: prevalence, pathophysiology, treatment. More papers from this issue can be found at http://www.eurojnlofpsychotraumatol.net
Acknowledgements
This study was supported in part by a research grant that was awarded and administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) (TCN: W81XWH-11-2-0189; RY: W81XWH-13-1-0071, DoD W81XWH-10-2-0072, DoD W81XWH-08-2-0021), the National Institute for Mental Health (TCN: 5R01MH073978-04, 5R34MH077667-03; EES: R01 MH097276), the National Institute on Aging (EES; R01 AG046170), the Veterans Health Research Institute, and the Mental Illness Research and Education Clinical Center of the US Veterans Health Administration.
Conflict of interest and funding
There is no conflict of interest in the present study for any of the authors.
Notes
For the abstract or full text in other languages, please see Supplementary files under Article Tools online
This paper is part of the Special Issue: PTSD in the military: prevalence, pathophysiology, treatment. More papers from this issue can be found at http://www.eurojnlofpsychotraumatol.net