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Original Articles

Oral misoprostol for preventing postpartum haemorrhage in home births in rural Bangladesh: how effective is it?

, , , &
Article: 7017 | Received 05 Mar 2011, Accepted 18 Jul 2011, Published online: 10 Aug 2011
 

Abstract

Aims : Evidence exists about prevention of postpartum haemorrhage (PPH) by oral administration of misoprostol in low-income countries, but effectiveness of prevention by lay community health workers (CHW) is not sufficient. This study aimed to investigate whether a single dose (400 µg) of oral misoprostol could prevent PPH in a community home-birth setting and to assess its acceptability and feasibility among rural Bangladeshi women.

Methods : This quasi-experimental trial was conducted among 2,017 rural women who had home deliveries between November 2009 and February 2010 in two rural districts of northern Bangladesh. In the intervention district 1,009 women received 400 µg of misoprostol immediately after giving birth by the lay CHWs, and in the control district 1,008 women were followed after giving birth with no specific intervention against PPH. Primary PPH (within 24 hours) was measured by women's self-reported subjective measures of the normality of blood loss using the ‘cultural consensus model.’ Baseline data provided socio-economic, reproductive, obstetric, and bleeding disorder information.

Findings : The incidence of primary PPH was found to be lower in the intervention group (1.6%) than the control group (6.2%) (p<0.001). Misoprostol provided 81% protection (RR: 0.19; 95% CI: 0.08–0.48) against developing primary PPH. The proportion of retained and manually removed placentae was found to be higher in the control group compared to the intervention group. Women in the control group were more likely to need an emergency referral to a higher level facility and blood transfusion than the intervention group. Unexpectedly few women experienced transient side effects of misoprostol. Eighty-seven percent of the women were willing to use the drug in future pregnancy and would recommend to other pregnant women.

Conclusion : Community-based distribution of oral misoprostol (400 µg) by CHW appeared to be effective, safe, acceptable, and feasible in reducing the incidence of PPH in rural areas of Bangladesh. This strategy should be scaled up across the country where access to skilled attendance is limited.

Acknowledgements

The study was supported by grants from the AusAID, the DFID, and the Netherlands government. We appreciate the help of BRAC in Bangladesh in carrying out the study. We would also like to express our thanks to the women who participated in the study for generously giving their time and energy to complete the interviews. All authors (HEN, SN, KA, MM, PB) participated in the planning and conception of the research questions and the study design. HEN was the principal investigator of the study and primarily conceptualised the research. MM was responsible for retrieving the data and HEN, SN, and MM were responsible for analysing the data. HEN drafted the article and all authors participated in interpreting the data and critically revising the manuscript for important intellectual content. All authors read and approved the revised manuscript.