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Abstract
We report the rare event of two imported cases in the Netherlands presenting with renal syndrome caused by Dobrava (DOBV)/Saaremaa (SAAV) hantaviruses. DOBV/SAAV hantaviruses are not circulating in the Netherlands and their clinical manifestation is typically more severe than that of the endemic Puumala virus (PUUV). This report aims to increase awareness among healthcare professionals and diagnostic laboratories to consider different hantaviruses as a cause of renal failure.
Acknowledgements
Ada van Staalduinen and Sandra Scherbeijn are thanked for excellent technical assistance. Barteld de Jongh is thanked for useful discussion about case 1. Kristel Fraaij-Grotenhuis is acknowledged for referring case 2 to the Harbour Hospital in Rotterdam. This study was partially funded by EU grant FP7-261504 EDENext and is catalogued by the EDENext Steering Committee as EDENext439 (www.edenext.eu). The contents of this publication are the sole responsibility of the authors and don't necessarily reflect the views of the European Commission. The Viroscience reference laboratory received funding from H2020 programs EMERGE (grant agreement no. 677066) and EVAg (grant agreement no. 653316) and the National Institute for Public Health and the Environment.