Chronobiological and morphofunctional aspects of arterial hypertension under circumpolar conditions

Abstract

Introduction. Nowadays the problem of population health in the northern areas is of great importance. While evaluating human adaptation to the extreme geoecological northern conditions the state of the cardiovascular system can be used as an index of effective compensatory adaptation. Study design. The data on 24-hour BP monitoring, data of echocardiography and heliogeophysical factors in different periods of ontogenesis in 317 patients, living in the north of the Tyumen region, were analysed to estimate the morphofunctional and chronobiological peculiarities of arterial hypertension. Results. Considerable disorders of haemodynamic circadian rhythms, manifesting either insufficient decrease of BP at night are revealed in the examined subjects. Above 42.2% of such patients have myocardial hypertrophy. Insufficient night decrease of BP is typical for the examined patients, with coupling of the indices of haemodynamic and current geomagnetic activity. The peculiarities of heliogeophysical factors at early ontogenesis of the examined subjects with an increased variability and decreased circadian index of BP are defined using multivariate analysis. Conclusion. Thus, a combination of disorders of temporary haemodynamic organisation with the morphological changes of myocardium and peculiarities of biogeophysical coupling of the examined is shown. This anthropoecological approach can be used for the diagnostics and treatment of arterial hypertension under conditions of the northern ecosystem.

Key Words:

• arterial hypertension
• 24-hour BP monitoring
• chronobiological