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Journal of Extracellular Vesicles Volume 4, 2015 - Issue 1
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Original Research Articles

Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day

Chris GardinerNuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, John Radcliffe Hospital, Oxford, UKCorrespondence[email protected]
,
Paul HarrisonSchool of Immunity and Infection University of Birmingham Medical School, Birmingham, UK
,
Mattias BeltingDepartment of Oncology and Pathology Clinical Sciences, Skåne University Hospital, Lund, Sweden
,
Anita BöingDepartment of Clinical Chemistry Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
,
Elena CampelloDepartment of Cardiologic Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy
,
Bob S. CarterDivision of Neurosurgery University of California San Diego, La Jolla, CA, USA
,
Mary E. CollierDepartment of Cardiovascular Sciences University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK
,
Frank CoumansDepartment of Clinical Chemistry Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands;Department of Biomedical Engineering and Physics Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
,
Camille EttelaieSchool of Biological Biomedical and Environmental Sciences, The University of Hull, Hull, UK
,
Nick van EsDepartment of Vascular Medicine Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
,
Fred H. HochbergDivision of Neurosurgery University of California San Diego, La Jolla, CA, USA;Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
,
Nigel MackmanThrombosis and Hemostasis Program Department of Medicine, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
,
Robert C. RennertDivision of Neurosurgery University of California San Diego, La Jolla, CA, USA
,
Johannes ThalerClinical Division of Haematology and Haemostaseology Department of Medicine I, Medical University of Vienna, Vienna, Austria
,
Janusz RakDepartment of Pediatrics McGill University, Montreal Children's Hospital Research Institute MUHC, Montreal, QC, Canada
&
Rienk NieuwlandDepartment of Clinical Chemistry Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
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Article: 26901 | Received 12 Jul 2014, Accepted 18 Feb 2015, Published online: 13 Mar 2015
 
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Abstract

Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor–bearing extracellular vesicles have been proposed as a possible explanation for the increased risk of VTE observed in some types of cancer. The International Society for Extracellular Vesicles (ISEV) and International Society on Thrombosis and Haemostasis (ISTH) held a joint Educational Day in April 2014 to discuss the latest developments in this field. This review discusses the themes of that event and the ISEV 2014 meeting that followed.

Conflict of interest and funding

The authors have not received any funding or benefits from industry or elsewhere to conduct this study.

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