Extracellular RNAs: development as biomarkers of human disease

Joseph F. QuinnDepartment of Neurology, Oregon Health & Science University, Portland, OR, USACorrespondence[email protected] [email protected]

Tushar PatelDepartments of Transplantation and Cancer Biology Mayo Clinic, Jacksonville, FL, USA

David WongSchool of Dentistry Department of Head and Neck Surgery, University of California at Los Angeles, Los Angeles, CA, USA

Saumya DasDivision of Cardiology Beth Israel Deaconess Medical Center, Boston, MA, USA

Jane E. FreedmanDepartment of Medicine University of Massachusetts Medical School, Worcester, MA, USA

Louise C. LaurentDepartment of Reproductive Medicine University of California at San Diego, San Diego, CA, USA

Bob S. CarterDepartment of Neurosurgery University of California at San Diego, San Diego, CA, USA

Fred HochbergDepartment of Neurosurgery University of California at San Diego, San Diego, CA, USA

Kendall Van Keuren-JensenTranslational Genomics Research Institute Phoenix, AZ, USA

Matt HuentelmanTranslational Genomics Research Institute Phoenix, AZ, USA

Robert SpetzlerBarrow Neurological Institute Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA

M. Yashar S. KalaniBarrow Neurological Institute Department of Neurological Surgery, St. Joseph's Hospital & Medical Center, Phoenix, AZ, USA

Jorge ArangoBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA

P. David AdelsonBarrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA

Howard L. WeinerAnn Romney Center for Neurologic Disease Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Roopali GandhiAnn Romney Center for Neurologic Disease Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Beatrice GoilavDivision of Pediatric Nephrology Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA

Chaim PuttermanDivision of Rheumatology and Department of Microbiology and Immunology Albert Einstein College of Medicine, Bronx, NY, USA

Julie A. SaugstadDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR, USACorrespondence[email protected] [email protected]

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Abstract

Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and cerebrospinal fluid. The disorders studied include hepatic and gastric cancer, cardiovascular disease, chronic kidney disease, neurodegenerative disease, brain tumours, intracranial haemorrhage, multiple sclerosis and placental disorders. Progress to date and the plans for future studies are outlined.

Keywords

This paper is part of the Special Issue: Extracellular RNA Communication Consortium. More papers from this issue can be found at http://www.journalofextracellularvesicles.net

Acknowledgements

We thank the NIH Common Fund for support these studies, via the NCATS UH2/UH3 Grants TR000931; TR000890; TR000921; TR000891; TR000906; TR000884; TR000903; TR000901; TR000923; TR000933. Also supported by NIA-AG08017. We also thank Dr. Thomas Tuschl and Dr. Manikkam Suthanthiran for feedback regarding this review.

Notes

This paper is part of the Special Issue: Extracellular RNA Communication Consortium. More papers from this issue can be found at http://www.journalofextracellularvesicles.net

Extracellular RNAs: development as biomarkers of human disease

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Extracellular RNAs: development as biomarkers of human disease

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