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Special Issue: Extracellular RNA communication Consortium

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium

Peter J. QuesenberryDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USACorrespondence[email protected]

Jason AliottaDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USA

Giovanni CamussiDepartment of Medical Sciences University of Turin, Torino, Italy

Asim B. Abdel-MageedDepartment of Urology Tulane University School of Medicine, New Orleans, LA, USA;Tulane Cancer Center Tulane University School of Medicine, New Orleans, LA, USA

Sicheng WenDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USA

Laura GoldbergDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USA

Huang-Ge ZhangDepartment of Microbiology and Immunology University of Louisville, Louisville, KY, USA

Ciro TettaDepartment of Medical Sciences University of Turin, Torino, Italy

Jeffrey FranklinDepartment of Molecular Biology Vanderbilt University, Nashville, TN, USA

Robert J. CoffeyDepartment of Molecular Biology Vanderbilt University, Nashville, TN, USA

Kirsty DanielsonDepartment of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Vinita SubramanyaDepartment of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Ionita GhiranDepartment of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Saumya DasDepartment of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

Clark C. ChenDepartment of Surgery Center for Theoretical and Applied Neuro-Oncology, University of California, San Diego, CA, USA

Kae M. PusicDepartment of Neurology University of Chicago, Chicago, IL, USA

Aya D. PusicDepartment of Neurology University of Chicago, Chicago, IL, USA

Devasis ChatterjeeDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USA

Richard P. KraigDepartment of Neurology University of Chicago, Chicago, IL, USA

Leonora BalajDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA

Mark DoonerDepartment of Medicine The Warren Alpert Medical School of Brown University, Providence, RI, USA

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Abstract

The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future.

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This paper is part of the Special Issue: Extracellular RNA Communication Consortium. More papers from this issue can be found at http://www.journalofextracellularvesicles.net

Acknowledgements

Xandra O. Breakefield, general, financial and material support U19 CA179563 supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director.

1UH2TR000880 (Peter Quesenberry, MD) Agency: NIH/NIDDK.

We are grateful to the James Graham Brown Cancer Center, University of Louisville. Our special thanks extends to Dr. Donald M Miller (Principal Investigator and Director of the Cancer Center) and Dr. Rebecca Redman (Co-Principal Investigator) from the James Graham Brown Cancer Center for both clinical trials. This work was supported by grants from the National Institutes of Health (NIH) (UH2TR000875) and the Louisville Veterans Administration Medical Center (VAMC) Merit Review Grants (H.-G.Z.).

Vanderbilt University, Nashville, TN: R01 CA163563, U19 CA179514, P50 CA095103 (SPORE).

NIH-NCATS (1UH2 TR000928-02). Department of Urology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112.

Notes

This paper is part of the Special Issue: Extracellular RNA Communication Consortium. More papers from this issue can be found at http://www.journalofextracellularvesicles.net

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium

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Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium

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