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Original Articles

Atherosclerosis: An Infectious Disease?

Pages 79-90 | Published online: 24 Jun 2015
 

Abstract

Traditional risk factors do not fully account for atherogenesis. There is increasing evidence that infectious pathogens, such as Helicobacter pylori, cytomegalovirus, and Chlamydia pneumoniae, may promote the atherosclerotic cascade. Proposed mechanisms include macrophage transformation, endothelial injury, chronic inflammation, and thrombosis. Specific antibiotic therapy may affect outcome.

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