Heparin-induced thrombocytopenia

PREVIEW

Indications for heparin therapy are broadening, and consequently, the incidence and risk of heparin-induced thrombocytopenia are increasing. Although risk is dose-dependent, any heparin preparation at any dose can induce a reaction. There are few reported cases of heparin-treated patients having serious bleeding; however, as discussed by Drs Kelton and Warkentin, major thrombotic complications can occur, leading to outcomes as serious as amputation, myocardial infarction, or stroke. This review discusses relative risk, signs and symptoms, diagnosis, causes, and alternative therapies that can be used in the management of these patients.