Monitoring blood levels of selected drugs

Remember to factor in the many confounding variables

Daniel E. Keyler Dr Keyler is codirector, toxicology research, Minneapolis Medical Research Foundation and department of medicine, division of clinical pharmacology and toxicology, Hennepin County Medical Center, and clinical associate professor, College of Pharmacy, University of Minnesota Medical School, Minneapolis.Correspondence[email protected]

, PharmD,

John T. VanDeVoort Dr VanDeVoort is a postdoctoral fellow, College of Pharmacy, University of Minnesota Medical School. Ms Howard and Dr Jancik are clinical pharmacists, department of pharmacy, and Dr Garrett is division chief, department of medicine, Hennepin County Medical Center.

, PharmD,

Jan E. Howard Dr VanDeVoort is a postdoctoral fellow, College of Pharmacy, University of Minnesota Medical School. Ms Howard and Dr Jancik are clinical pharmacists, department of pharmacy, and Dr Garrett is division chief, department of medicine, Hennepin County Medical Center.

, BSPharm, BCPS,

Jon T. Jancik Dr VanDeVoort is a postdoctoral fellow, College of Pharmacy, University of Minnesota Medical School. Ms Howard and Dr Jancik are clinical pharmacists, department of pharmacy, and Dr Garrett is division chief, department of medicine, Hennepin County Medical Center.

, PharmD, BCPS &

Craig R. Garrett Dr VanDeVoort is a postdoctoral fellow, College of Pharmacy, University of Minnesota Medical School. Ms Howard and Dr Jancik are clinical pharmacists, department of pharmacy, and Dr Garrett is division chief, department of medicine, Hennepin County Medical Center.

, MD

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Measuring the serum concentration of pharmacologic agents may be helpful in confirming treatment efficacy and may help explain adverse events. However, timing of the last dose, concomitant drug use, serum half-life, preexisting conditions, and even recent physical activity can alter results. Errors in interpretation and in application of findings can amplify problems. The authors describe how to achieve optimal therapy with six commonly selected agents by practicing vigilance and educated integration of laboratory and clinical information.

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Monitoring blood levels of selected drugs

Remember to factor in the many confounding variables

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Monitoring blood levels of selected drugs

Remember to factor in the many confounding variables

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