PREVIEW
The risk of Lyme disease correlates with the presence of tick vectors, the prevalence of suitable reservoir hosts for Borrelia burgdorferi, and certain human activities that increase risk of exposure to infected ticks. Diagnosis hinges on an accurate assessment of risk and an understanding of the clinical spectrum of the disease. In this article, Drs Rahn and Felz review the primary clinical manifestations of Lyme disease and discuss the chief issues in diagnosis and treatment.