When to try COX-2-specific inhibitors

Safer than standard NSAIDs in some situations

Qaiser Rehman Dr Rehman is a rheumatology subspecialty fellow and Dr Sack is professor of clinical medicine, division of rheumatology, department of medicine, University of California, San Francisco, School of Medicine. Dr Sack is also director, clinical programs in rheumatology.

, MD &

Kenneth E. Sack Dr Rehman is a rheumatology subspecialty fellow and Dr Sack is professor of clinical medicine, division of rheumatology, department of medicine, University of California, San Francisco, School of Medicine. Dr Sack is also director, clinical programs in rheumatology.Correspondence[email protected]

, MD

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Cyclooxygenase-2 (COX-2) inhibitors are the latest addition to the growing armamentarium of anti-inflammatory drugs. Their ability to selectively block formation of proinflammatory prostaglandins while sparing those that guard the gastrointestinal tract makes them an attractive choice for long-term use, such as in rheumatic disease. More COX-2 inhibitors will undoubtedly become available, so primary care physicians should be aware of their advantages and limitations. In this article, the authors describe the pharmacokinetics and use of these agents.

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When to try COX-2-specific inhibitors

Safer than standard NSAIDs in some situations

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When to try COX-2-specific inhibitors

Safer than standard NSAIDs in some situations

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