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PREVIEW
Hepatocellular cancer is one of the most common cancers in the world. It is also one of the most deadly, with a 5-year survival rate of less than 5% without treatment. And investigators have added a note of alarm to this already grim scene—the incidence of the disease is on the rise in the United States. Primary care physicians have a critical role because they are often the first to see these patients. In this article, Dr Ulmer discusses how increased knowledge of the pathogenesis of hepatocellular carcinoma and advances in detection, prevention, and treatment have made possible discovery of this aggressive tumor at potentially treatable stages.