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PREVIEW
Treatment of type 2 diabetes has become more and more complex as the number of classes of oral antidiabetic agents has increased. Diet, exercise, and the attainment of ideal body weight are the central components of any therapeutic regimen, but most patients are unable to achieve glycemic goals with these measures alone. In this article, Drs Mayerson and Inzucchi review the five classes of available oral antidiabetic agents and discuss their relationship to the pathophysiologic variables that contribute to hyperglycemia in type 2 diabetes.