ARBs and target organ protection

Exploring benefits beyond their antihypertensive effects

Russell L. Silverstein Dr Silverstein is senior physician and vice president, Dallas Nephrology Associates, Dallas.Correspondence[email protected]

, MD,

Andrew Z. Fenves Dr Fenves is director of nephrology, Baylor University Medical Center, and senior physician, Dallas Nephrology Associates, Dallas.

, MD &

C. Venkata S. Ram Dr Ram is medical director, Texas Blood Pressure Institute, Dallas, and clinical professor of medicine, Southwestern Medical School, University of TexasSouthwestern Medical Center at Dallas.

, MD

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Recognition of the role of the renin-angiotensin-aldosterone system (RAAS) in initiating and maintaining hypertension prompted the development of drugs that disrupt the RAAS, notably the angiotensin-converting enzyme (ACE) inhibitors and, more recently, the angiotensin II receptor blockers (ARBs). This article focuses on the use of ARBs in hypertension management and reviews evidence emerging from clinical trials that ARBs offer target organ protection over and above their antihypertensive activity.

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ARBs and target organ protection

Exploring benefits beyond their antihypertensive effects

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ARBs and target organ protection

Exploring benefits beyond their antihypertensive effects

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