Asterixis Related to Gabapentin Intake: A Case Report and Review

Abstract

Asterixis has been reported as a side effect of toxic and metabolic abnormalities. The current literature contains very little evidence of gabapentin-related neurotoxicity. Our observations reveal that neurotoxic side effects of gabapentin use may be seen even when dose adjustments are made for patients with mild-to-moderate renal dysfunction. Clinical vigilance for possible neurotoxic effects of gabapentin therapy in patients with renal dysfunction is warranted.

Keywords:

• asterixis
• subcortical myoclonus
• negative myoclonus
• gabapeptin