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Abstract
Aim: Electromembrane extraction (EME) of 37 drugs of abuse with significant differences in terms of polarity (0.68<log P <4.3) and basicity (1.17<pKa<10.38) was investigated from human plasma. Materials & methods: EME was performed with 250mM trifluoroacetic acid and DMSO (1:1 v/v) in the acceptor solution. Results & conclusion: The analytes were extracted efficiently with pure 2-nitrophenyloctyl ether as supported liquid membrane when the acceptor solution was modified with DMSO. Thus, using DMSO mixed with 250mM trifluoroacetic acid (1:1, v/v) as acceptor solution, recoveries from 40 to 105% (relative standard deviation<20%) were obtained for 33 of the analytes under optimized conditions. EME followed by ultra-HPLC–MS/MS analysis was evaluated from human plasma, and the results were satisfactory.
Supplementary data
See online at: https://www.tandfonline.com/doi/10.4155/bio-2018-0308
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: https://www.tandfonline.com/doi/suppl/10.2144/000112170