Financial & competing interests disclosure
Financial support through the US NIH (R01NS081180 to TR Holman and R21NS087165 to K van Leyen) is gratefully acknowledged. Patents for LOXBlock-1 and for ML351 have been applied for. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.