Abstract
Since its serendipitous discovery over 30 years ago, the translocator protein (18 kDa) has been demonstrated to play an important role in a multitude of critical biological processes. Although implemented as a novel therapeutic and diagnostic tool for a variety of disease states, its most promising role is as a molecular target for anticancer treatments such as photodynamic therapy (PDT). This review gives an overview of the attempts made by researchers to design porphyrin-based photosensitizers for use as anticancer therapeutics in PDT as well as improved imaging agents for diagnostic purposes. With a better understanding of the structure and function of the translocator protein, the synthesis of porphyrins for use in PDT with optimum binding affinities will become ever more possible.
Financial & competing interest disclosure
This work was supported by a grant from Science Foundation Ireland (SFI) (P.I. 09/IN.1/B2650). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.