Abstract
The emergence of antimicrobial resistance has created a need for the development of novel antibacterial therapies to treat infection. Natural products that exhibit antibacterial activity offer validated starting points for library generation, and the authors report here that small molecule mimics of tetramate-containing natural products may show antibacterial activity and offer the potential for further optimization.
Acknowledgements
The authors are particularly grateful to Phil Dudfield and John Lowther for valuable input.
Financial & competing interests disclosure
Y-C Jeong and MG Moloney received funding from Galapagos SASU (France). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.