Financial & competing interests disclosure
Recent work on DHFR catalysis in our laboratory has been funded by the UK's Biotechnology and Biological Sciences Research Council (BBSRC) through grants BB/J005266/1 and BB/L020394/1, by the Life Science Research Network Wales and Cardiff University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.