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Abstract
Aim: Super absorbent polyvinyl alcohol-sodium acrylate copolymer microspheres, Quadrasphere microspheres (QSM), are commonly used for drug-eluting bead therapy, however, the literature only reports its use with small molecule chemotherapeutics. This study evaluates the loading and elution characteristics of bevacizumab-loaded QSM. Methods & results: A single vial of QSM was reconstituted with 200 mg of bevacizumab. Drug concentration was determined by ELISA immunoassay. At approximately 90 min, there was maximal loading at 59% of the starting dose. In vitro elution demonstrated 52% of bound bevacizumab was released within the first hour and 68% by 16 h. Conclusion: Bevacizumab can load onto QSM and elute over time. This targeted delivery vehicle may potentially result in more effective treatment and fewer complications related to systemic toxicity.
Acknowledgements
The authors would like to thank C Zeng, for her image analysis and H Collins, for her assistance with the ELISA. The study was supported by the UPENN Neuroradiology Research Core Fund.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.