Curcumin Sensitizes Chemotherapeutic Drugs Via Modulation of PKC, telomerase, NF-κB and HDAC in Breast Cancer

Abstract

Background: Several tumor markers are overexpressed in breast cancer. Chemotherapy in breast cancer fails due to resistance to chemotherapeutic drugs. A phytochemical such as curcumin can be used in a therapeutic modality as it elicits anti-tumor effects. Methods: Action of curcumin on the expression of several tumor markers, such as protein kinase C, telomerase, NF-κB and histone deacetylase in MCF-7 (ER positive), MDA-MB-231 (ER negative), MCF-12F (control) and also in mice mammary tumors were investigated. Results: Curcumin downregulated the expression of tumor markers both in vitro and in vivo and sensitized tumor cells to the chemotherapeutic drugs cyclophosphamide and paclitaxel. Discussion: Curcumin may be of considerable value in synergistic therapy of cancer such that the drug dose level could be minimized reducing the associated toxicity.

Acknowledgements

The authors gratefully acknowledge Chittaranjan National Cancer Institute for providing infrastructural facilities.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Financial & competing interests disclosure

The authors gratefully acknowledge Department of Science Technology, New Delhi, India, for their financial assistance in executing this research work. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.