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Abstract
Background: Benzoyl peroxide (BPO) has been a mainstay of topical acne treatment for years. However, is frequently accompanied by cutaneous irritation and erythema. To reduce these side effects many novel drug delivery systems have been developed in the past, of which solid lipid nanoparticles (SLN) demonstrate clear dominance. Hence, we developed a facile method to prepare stable SLN of BPO and evaluated their anti-bacterial activity. Results: BPO-SLN optimized using 23 full factorial design provided high occlusion factor, low permeation rate, increased drug deposition, reduced skin irritation and strong anti-bacterial activity in contrast with marketed product. Conclusion: Desired goals were achieved by factorial design approach in shortest possible time with minimum number of experiments. The developed BPO-SLN system provided controlled drug release, thereby reducing the well-known side effects.
Acknowledgements
The authors would like to thank Gattefosse and Lubrizol for providing gift samples of the excipients.
Financial & competing interests disclosure
The authors are grateful for financial support from All India Council for Technical Education, New Delhi (F. No. 8023/BOR/RID/ RPD-126/2009-10 Dt. 31/03/2010). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The study protocol was approved by Institutional Animal Ethical Committee (IAEC) constituted as per guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals), Government of India.