Spherulites: onion-like Vesicles As Nanomedicines

Abstract

Spherulites are onion-like structures composed of phospholipids and excipients. Initially discovered in an academic laboratory, these autoassembled nano-objects have been developed further by the start-up Capsulis (Bordeaux, France), and commercialized for veterinary and dermatological applications. Owing to economical strategies, the development of these objects have not been pursued, however, they are very interesting systems, which should be exploited further. The autoassembly of amphiphiles followed by a shear stress allows the formation of nano- to micrometer range nanoparticles, which could be interesting either for systemic or local delivery. Small molecules to macromolecules have been encapsulated in spherulites in the nanometer range. All have shown promising results. Hence, spherulite-encapsulated oligonucleotides have shown increased cell internalization. DNA was shown to be encapsulated in these neutral nanoparticles. Proof-of-concept of protein encapsulation was obtained leading to immune stimulation. This review summarizes the different ways to obtain spherulites, the results of the various investigations performed to date and indicates the limits and the interests of theses nanocarriers and proposes future prospects.

Financial & competing interests disclosure

The work was supported by the University Paris Descartes (Projet Collaboratif: spherulites). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.